LC-MS/MS Targeted PFAS Quantification
topic
Targeted PFAS analysis extracts textile specimens with methanol or acetonitrile under ultrasonication, concentrates extracts by solid phase extraction on mixed-mode anion exchange cartridges, and quantifies individual PFAS compounds by LC-MS/MS with electrospray ionisation against isotope-labelled internal standards; methods typically cover 30 to 80 individual PFAS analytes across carboxylate, sulfonate, sulfonamide, and fluorotelomer compound classes.
Role
Provides the quantitative PFAS compound profile required for REACH SVHC notification compliance, bluesign and OEKO-TEX PFAS limits verification, and fluorine-free alternative validation, covering PFOA, PFOS, and their precursors at detection limits well below regulatory thresholds in textile matrices.