Electrospun Nanofiber Wound Dressing

Electrospun wound dressings use biocompatible polymers (PCL at 10–15 wt% in DCM:DMF 3:1, PVA at 10 wt% in water, gelatin at 15 wt% in HFIP) deposited at 12–20 kV to produce 200–600 nm fiber mats at 20–50 g/m² basis weight. Porosity of 80–90% supports oxygen permeability (>2,000 g/m²/24h MVTR) and prevents bacterial ingress (pore diameter 0.5–2.0 µm). Drug-loaded nanofibers (tetracycline or silver sulfadiazine at 5–15 wt%) achieve sustained release over 7–14 days matching wound healing kinetics. Wound exudate absorption capacity of 5–15 g/g is comparable to commercial hydrocolloid dressings. In vivo wound closure 30–40% faster than gauze in diabetic wound models. ISO 10993-5 cytotoxicity testing confirms cellular biocompatibility at standard therapeutic loadings.